Publications (click on title for pdf)

Published (or in press).

270. Robinson, J.I. and S. M. Beverley, (2018), “Concentration of 2’C-methyladenosine triphosphate by Leishmania guyanensis enables specific inhibition of the Leishmania RNA virus 1 polymerase”, J. Biol. Chem., (in press) (deposited in bioRxiv preprint server, PMCID: in process

269. Brettmann, E.A., L-F. Lye, and S.M. Beverley (2018), “Spontaneous excision and facilitated recovery as a control for phenotypes arising from RNA interference and other dominant transgenes”, Molec. Biochem. Parasitol. 220:42-45

268. Hartley, M-A., R. O. Eren, F. Prevel, M. Rossi, P. Castiglioni, N. Isorce, C. Desponds, L-F. Lye, S. M. Beverley, S. K. Drexler &, N. Fasel (2018), “Leishmania guyanensis parasites block the activation of the inflammasome by inhibiting maturation of IL-1b”, (Microbial Cell in press) PMCID:  in process.

267. Grybchuk, D., N. S. Akopyants$, A. Y. Kostygov$, A. Konovalovas, L-F Lye, D. E. Dobson, H. Zangger, N. Fasel, A. Butenko, A. O. Frolov, J. Votýpka, C. M. d'Avila-Levy, P. Kulich, J. Moravcová, P. Plevka, I. B. Rogozin, S. Serva, J. Lukeš, S.M. Beverley*, and V. Yurchenko*, (2017), “Viral discovery and diversity in trypanosomatid protozoa with a focus on relatives of the human parasite Leishmania ”, Proc. Natl. Acad. Sci. USA 115(3): E506-E515.  $,* authors contributed equally to this manuscript. PMCID: PMC5776999

266. Iantorno. S., C. Durrant, A. Khan, M. J. Sanders, S.M. Beverley, W. Warren, M. Berriman, D. L. Sacks, J. A. Cotton, and M. E. Grigg (2017), “Gene Expression in Leishmania Is Regulated Predominantly by Gene Dosage”,mBio 12;8(5). pii: e01393-17.   PMCID: PMC5596349

265. Eren, R. O., D. Kopelyanskiy, D. Moreau, J.B. Chapalay, M. Chambon, G. Turcatti, L-F. Lye, S. M. Beverley, and N. Fasel (2017), “Development of a semi-automated image-based high-throughput drug screening system”, Frontiers in Biosciences (Elite Ed.) 10: 242-253.  PMCID:  PMC5735416

264. Guo, H., N. M. Novozhilova, G. Bandini, S.J. Turco, M. A. J. Ferguson and S. M. Beverley (2017), “Genetic Metabolic Complementation Establishes a Requirement for GDP-Fucose in Leishmania”, J. Biol. Chem 292: 10696-10708. PMCID: PMC5481574.

263. Rossi, M, P. Castiglioni, M-A. Hartley, R. O. Eren, F. Prével, C. Desponds, D. T. Utzschneider, D. Zehn, M. G. Cusi, F. M. Kuhlmann, S. M. Beverley, C. Ronet, and N. Fasel (2017), “Type I interferons induced by endogenous or exogenous viral infections promote metastasis and relapse of leishmaniasis”, Proc. Natl. Acad. Sci. USA 114: 4987-4992. PMCID: PMC5441690.

262. Matveyev, J.M. P., Alves, M. G. Serrano, V. Lee, A. M. Lara, W. A. Barton, S. M. Beverley, E. P. Camargo, M. M. G. Teixeira, and G. A. Buck (2017), “The Evolutionary Loss of RNAi Key Determinants in Kinetoplastids as a Multiple Sporadic Phenomenon”, J Mol Evol. 84: 104-115. PMCID: PMC5744689.

261. Mandell, M.A. and S. M. Beverley (2017), “Continual renewal and replication of persistent Leishmania major parasites in concomitantly immune hosts”, Proc. Natl. Acad. Sci. USA 114(5):E801-E810. PMCID: PMC5293024.

260. Castiglioni, Pr., M-A. Hartley, M. Rossi1, F. Prevel, C. Desponds, D. T. Utzschneider, R-O. Eren, H. Zangger, L. Brunner, N. Collin, D. Zehn, F. M. Kuhlmann, S. M. Beverley, N. Fasel and C. Ronet (2017), “Exacerbated Leishmaniasis Caused by a Viral Endosymbiont can be Prevented by Immunization with Its Viral Capsid”, PLoS Neglected Tropical Diseases 11(1):e0005240. PMCID: PMC5242429.

259. Kuhlmann, F.M. J.I. Robinson, G. Bluemling, C. Ronet, N. Fasel, and S.M. Beverley (2017), “Anti-viral Screening Identifies Adenosine Analogs Targeting the Endogenous dsRNA Leishmania RNA Virus 1 (LRV1) Pathogenicity Factor”, Proc. Natl. Acad. Sci. USA 114: E811-E819. PMCID:  PMC5293060.

258. Guimarães, L.H., A. Queiroz, J. A. Silva, S. C. da Silva, V. Magalhães, E. L. Lago, P. R. L. Machado, O. Bacellar, M. E. Wilson, S. M. Beverley, E. M. Carvalho, and A. Schriefer (2016), “Atypical manifestations of cutaneous leishmaniasis in a region endemic for Leishmania (Viannia) braziliensis: clinical, immunological and parasitological aspects”, PLoS Neglected Tropical Diseases 10(12):e0005100. PMCID:  PMC5131895.

257. Brettmann, E.A., J. Shaik, H. Zangger, L-F. Lye, F. M. Kuhlmann, N. S. Akopyants, D. M. Oschwald, K.L. Owens, S. M. Hickerson, C. Ronet, N. Fasel, and S. M. Beverley, (2016), “Tilting the balance between RNA interference and replication eradicates Leishmania RNA virus 1 and mitigates the inflammatory response”, Proc. Natl. Acad. Sci. USA 10(12):e0005100. PMCID: PMC5131895.

256. Macedo, D.H., A. Menezes-Neto, J. M. Rugani, A. C. Rocha, S. O. Silva, M. N. Melo, L-F Lye, S.M. Beverley, C. M. Gontijo, and R. P. Soares, (2016), “Low frequency of LRV1 in Leishmania braziliensis strains isolated from typical and atypical lesions in the State of Minas Gerais, Brazil”, Mol. Biochem. Parasitol. 210: 50-54. PMCID: PMC5125831.

255. Hartley, M-A., E. Bourreau, M. Rossi, P. Castiglioni, R. Eren, F. Prevel, P. Couppié, S. Hickerson, P. Launois, S. Beverley, C. Ronet, and N. Fasel, (2016), Leishmania RNA virus-dependent metastatic leishmaniasis is mediated by IL-17A in the absence of IFN-γ”, PLoS Pathogens 12(9):e1005852. PMCID: PMC5033371.

254. Eren, R.O., M. Reverté, M. Rossi, M-A. Hartley, P. Castiglioni, F. Prevel, R. Martin, C. Desponds, L-F. Lye, S. K. Drexler, W. Reith, S. M. Beverley, C. Ronet, and N. Fasel (2016), “Mammalian Innate Immune Response to a Leishmania-Resident RNA Virus Increases Macrophage Survival to Promote Parasite Persistence”, Cell Host Microbe 20: 318-28. PMCID: NIHMS867188.

253. Akopyants, N.S., L-F. Lye, D.E. Dobson, J. Lukeš and S.M. Beverley (2016), “A novel bunyavirus-like virus of trypanosomatid protist parasites”, Genome Announcements (in press). PMCID in progress.

252. Lye, L-F., N.S. Akopyants, D.E. Dobson, and S.M. Beverley (2016), “A Narnavirus-like element from the trypanosomatid protozoan parasite Leptomonas seymouri”, Genome Announcements 4 e00713-16. PMCID: PMC4974305.

251. Akopyants, N.S., L-F. Lye, D.E. Dobson, J. Lukeš and S.M. Beverley (2016), “A Narnavirus in the trypanosomatid protist plant pathogen Phytomonas serpens”, Genome Announc. 4(4):e00711-16. doi:10.1128/genomeA.00711-16. PMCID: PMC4966457.

250. Mandell, M.A., and S.M. Beverley (2016), “Concomitant immunity induced by persistent Leishmania major does not preclude secondary re-infection: implications for genetic exchange, diversity and vaccination”, PLoS Neglected Tropical Diseases (in press). PMCID: 4924822.

249. Beverley, S.M., (2016), “African trypanosomes find a fat haven”, Cell Host Microbe 16: 748-9. PMCID: PMC4986830.

248. Reynolds, D.L., B. T. Hofmeister, L. Cliffe1, T. N. Siegel, B. A. Anderson, S. M. Beverley, R. J. Schmitz, and R. Sabatini (2016), “Base J represses genes at the end of polycistronic gene clusters in Leishmania major by promoting RNAP II termination and its endosymbiotic virus”, Molecular Microbiology 101: 559-74.  PMCID: PMC5038137.

247. Parmentier, L., A. Cusini, N. Müller, H. Zangger , M-A. Hartley, C. Desponds, P. Castiglioni, P. Dubach, C. Ronet, S. M. Beverley, and N. Fasel (2015), “Severe cutaneous leishmaniasis in an HIV patient co-infected with Leishmania braziliensis and its endosymbiotic virus”, American Journal of Tropical Medicine & Hygiene 94: 840-3. PMCID: PMC4824227

246. Favila, M.A, N.S. Geraci, N.S., A. Jayakumar, S. M. Hickerson, J. Mostromi, S.J. Turco, S. M. Beverley and M. A. McDowell (2015), “Differential impact of LPG-and PG-deficient Leishmania major mutants on the immune response of human dendritic cells”, PloS Neglected Tropical Diseases 9(12):e0004238. PMCID: PMC4667916.

245. Valdivia, H.O., J. L. Reis Cunha, G. F. Rodriguez-Luiz. R. P. Baptista. G. C. Baldeviano, R. V. Gerbasi, D. E. Dobson, F. Pratlong, P. Bastien, A.G. Lescano, S. M. Beverley, & D. C. Bartholomeu (2015), “Comparative genomic analysis of Leishmania (Viannia) peruviana and Leishmania (Viannia) braziliensis”, BMC Genomics 16:715. PMCID: PMC4575464.

244. Beverley, S.M. (2015), “CRISPR for Cryptosporidium”, Nature 523: 413-414. PMCID: PMC4620987.

243. Adaui, V., L-F. Lye, N. S. Akopyants, M. Zimic, A. Llanos-Cuentas, L. Garcia, I. Maes, S. De Doncker, D. E. Dobson, J-C. Dujardin, J. Arevalo & S.M. Beverley (2015), “Association of endobiont dsRNA virus LRV1 with treatment failure of human leishmaniasis caused by Leishmania braziliensis in Peru and Bolivi”, J. Infectious Diseases 213: 112-21. PMCID: PMC4676543.

242. Terrazas, C., St. Oghumu, S. Varikuti, D. Martinez-Saucedo, S.M. Beverley and Abhay Satoskar (2015), “Uncovering Leishmania-macrophage interplay using imaging flow cytometry”, J. Immunological Methods 653-7. PMCID: PMC4620550.

241. da Costa-Silva, T.A., S. S. Grecco, F, S. de Sousa, J. H. G. Lago, E. G. A. Martins, C.A. Terrazas, S. Varikuti, S.M. Beverley, A. Satoskar, and A.G. Tempone (2015), “Immunomodulatory and antileishmanial activity of phenylpropanoid dimers isolated from Nectandra leucantha”, J. Natural Products 78: 653-7. PMCID: in process.

240. Vasquez, M.A., U. Das, S. M. Beverley, E. Iniguez, L. J. Herrera, J.R. Dimmock, and R. A. Maldonado (2015), “Evaluation of α,β-unsaturated ketones as anti-parasitic agents”, Antimicrobial Agent and Chemotherapy 59:3598-601. PMCID: PMC4432202.

239. Shaik, J., A. Khan, S. M. Beverley and L.D. Sibley (2015), “REDHORSE-REcombination and Double crossover detection in Haploid Organisms using next-geneRation Sequencing data”, BMC Genomics 16: 133. PMCID: PMC4348101.

238. Damasceno JD, S. M. Beverley, L. R. Tosi (2015), “A transposon-based tool for transformation and mutagenesis in trypanosomatid protozoa”, Methods Mol Biol. 1201:235-45. PMCID: NIHMS649450.

237. Romano, A. E. Inbar, A. Debrabant, M. Charmoy, P. Lawyer, F. Ribeiro-Gomes, M. Barhoumi, M. Grigg, J. Shaik, D. Dobson, S. M. Beverley, D. L. Sacks, (2014), “Cross-species genetic exchange between visceral and cutaneous strains of Leishmania in the sand fly vector”, Proc Natl Acad Sci U S A. 111(47):16808-13. PMCID: PMC4250153. * - senior authors contributed equally.

236. Hartley, M., S. Drexler, C. Ronet, S. M. Beverley, and N. Fazel (2014), “The immunological, environmental, and phylogenetic perpetrators of metastatic leishmaniasis”, Trends in Parasitology 30(8):412-22. NIHMSID: 649448.

235. Campos-Salinas, J., A. Cavazzuti, F. O’Valle, I.Forte-Lago, M. Caro, S. M. Beverley, M. Delgado, and E. Gonzalez-Rey (2014), “Therapeutic efficacy of stable analogues of Vasoactive Intestinal Peptide against pathogens” induce pro-inflammatory cytokine responses”, J. Biological Chemistry 289(21):14583-99. PMCID: in process.

234. Zangger, H., A. Hailu, C. Desponds, L-F. Lye, N. S. Akopyants, D.E. Dobson, C. Ronet, H. Ghalib, S. M. Beverley and N. Fasel (2014), Leishmania aethiopica field isolates bearing an endosymbiontic dsRNA virus” induce pro-inflammatory cytokine responses”, PLoS Neglected Tropical Disease 8(4):e2836. PMCID: in process.

233. Beiting, D. P., L. Peixoto, N. S. Akopyants, S. M. Beverley , E. J. Wherry, D. A. Christian, C. A. Hunter, I. E. Brodsky and D. S. Roos. (2014), “Differential induction of TLR3-dependent innate immune signaling by closely related parasite species”, PLoS One 9(2):e88398. PMCID:PMC3914978

232. Hsu, F-F, F.M. Kuhlmann, J. Turk and S.M. Beverley. (2014), “Multiple-stage linear ion-trap with high resolution mass spectrometry towards complete structural characterization of phosphatidylethanolamines containing cyclopropane fatty acyl chain in Leishmania infantum”, J. Mass Spectrometry 49(3):201-9. NIHMS ID: 569612

231. Anderson, B. A., I. L. Wong, L. Baugh, G. Ramasamy, P. J. Myler, S. M. Beverley. (2013), “Kinetoplastid-specific histone variant functions are conserved in Leishmania major”, Mol Biochem Parasitol. 191(2):53-57. PMCID: in process.

230. Campos-Salinas J, Caro M, Cavazzuti A, Forte-Lago I, Beverley SM, O'Valle F, Gonzalez-Rey E. (2013), “Protective Role of the Neuropeptide Urocortin II against Experimental Sepsis and Leishmaniasis by Direct Killing of Pathogens.”, J Immunol 191(12):6040-51. PMID: 24249730.

229. Inbar, E., N. Akopyants, M. Charmoy, A. Romano, P. Lawyer, D-E. A. Elnaiem, F. Kaufmann, R. Patrick, M. Barhoumi, M. Grigg, M. Fay, K. Owens, D.E. Dobson, S.M. Beverley, and D. Sacks (2013), “The mating competence of geographically diverse Leishmania major strains in their natural and unnatural sand fly vectors”, PLoS Genetics 9(7):e1003672. PMCID: in process.

228. Liu, D., Z. Mou, I. Okwor, S. M. Beverley, and J. E Uzonna (2013), “Deficiency of Leishmania phosphoglycans influences the magnitude but does not affect the quality of secondary (memory) anti-Leishmania immunity”, PLoS One 8(6):e66058. PMCID: PMC3679009.

227. Mou, Z., H. M. Muleme, D. Liu, P. Jia, I.B. Okwor, S.M. Kuriakose, S.M. Beverley, and J.E Uzonna (2013), “Parasite-derived arginase influences secondary anti-Leishmania immunity by regulating PD-1-mediated T cell exhaustion”, J. Immunology, 190: 3380-9. PMCID: PMC3737427.

226. Heiss, C., M. L. Skowyra, H. Liu, J. S. Klutts, Z. Wang, M. Williams, D. Srikanta, S. M. Beverley, P. Azadi, and T. L. Doering, (2013), “Unusual galactofuranose modification of a capsule polysaccharide in the pathogenic yeast Cryptococcus neoformans J. Biol. Chem. 288:10994-1003. PMCID: PMC3630864.

225. Rocha, M. N, C. M. Corrêa, M. N. Melo, S. M. Beverley, O, A. Martins-Fillho. A. Paula Madureira, and R. P. Soares (2013), “An alternative in vitro drug screening test using Leishmania amazonensis transfected with red fluorescent protein” Diagnostic Microbiology & Infectious Diseases pii: S0732-8893(12)00501-9. PMCID: PMC3733281.

224. Zangger, H., C. Ronet, C. Desponds, F. M. Kuhlmann, J. Robinson, M-A Hartley, F. Prével, P. Castiglioni, F. Pratlong , P. Bastien, N. Müller, L. Parmentier, N. G. Saravia , S.M. Beverley, and N. Fasel (2013), “Detection of Leishmania RNA virus in Leishmania parasites” PLoS Neglected Tropical Diseases 7:e2006. PMCID: PMC3542153

223. Feng, X., D. Rodriguez-Contreras, T. Polley, L-F. Lye, D. Scott, R. J. S. Burchmore, S.M. Beverley and S.M. Landfear (2013), “Transient’ genetic suppression facilitates generation of hexose transporter null mutants in Leishmania mexicana Molecular Microbiology 87(2):412-29. PMCID: PMC3545093

222. Atayde, V.D., H. Shi, J. Franklin, N.J. Carriero, T. Notton, L-F. Lye, K. Owens, S.M. Beverley, C. Tschudi and E. Ullu (2013), “The structure and repertoire of small interfering RNAs in Leishmania (Viannia) braziliensis reveal diversification in the trypanosomatid RNAi pathway” Molecular Microbiology 87(3):580-93. PMCID: PMC3556230

221. Lezama-Davila, C., G. Kapadia, A. Marquez-Issac, K.L. Owens, S. Oghumu, S.M. Beverley, and A. Satoskar (2012), “Leishmanicidal activity of two naphthoquinones against Leishmania donovani Biological and Pharmacological Bulletin 35:1761-4. PMCID: PMC3693454.

220. Hartley, M-A., C. Ronet, H. Zangger, S. M. Beverley and N. Fasel (2012), Leishmania RNA virus: when the host pays the toll” Frontiers in Cellular Infection & Microbiology 2:99. PMCID: PMC3417650.

219. Laranjeira da Silva, M.F., R.A. Zampieri, S. M. Muxel, S.M. Beverley and L. M. Floeter-Winter (2012), "Leishmania amazonensis arginase compartmentalization in the glycosome is important for parasite infectivity" PLoS One 7(3):e34022. PMCID:3316525.

218.  Bruhn, K.W., Birnbaum, R., J. Haskell, V. Vanchinathan, S. Greger, R. Narayan, P. L. Chang, T.A. Tran, S. M. Hickerson, S. M. Beverley, M. E. Wilson, and N. Craft (2012), “Killed but metabolically active Leishmania is a novel whole-cell vaccine for visceral leishmaniasis" Clinical & Vaccine Immunology 19(4):490-8. PMCID:3318268.

217.  Franco, L., S.M. Beverley and D. S. Zamboni (2011), “Innate immune activation and subversion of mammalian functions by LeishmaniaLipophosphoglycan" J Parasitol Research 2012:165126. PMCID:3317186

216.  Ronet, C., S.M. Beverley and N. Fasel (2011), “Un virus, hôte indésirable
de L. guyanensis, détermine la gravité de la forme mucocutanée de la leishmaniose”
Médecine et Sciences 27(11):924-26. (in French) PMCID: PMC371776.

215.  Ronet, C., S.M. Beverley and N. Fasel (2011), “Muco-cutaneous leishmaniasis in the New World: the ultimate subversion” Virulence 2(6):547-552. PMCID:3260548

214.  Diaz-Gonzalez, R, F. M. Kuhlmann, C, Galan-Rodriguez, L. Madeira da Silva, C.E. Karver, A Rodriguez, S M. Beverley, M. Navarro, and M. P. Pollastri, “The susceptibility of trypanosomatid pathogens to PI3/mTOR kinase inhibitors affords a new opportunity for drug repurposing” PLoS Neglected Tropical Diseases 5: e1297. PMCID:3160303.

213.  Vickers, T.J. & S.M. Beverley, “Folate metabolic pathways in Leishmania (2011), Essays in Biochemistry 51:63-80. PMCID in process

212.  Wang, Y., L. Xin, V. Popov, S.M. Beverley, K-P Chang, M. Wang and L. Soong (2010), “The microbicidal effects of human histone proteins H2A and H2B on Leishmania promastigotes but not amastigotesInfection & Immunity 79:1124-33. PMCID:3067510.

211.  Ives, A., C. Ronet, F. Prevel, G. Ruzzante, S. Fuertes-Marraco, F. Schutz, H. Zangger, M. Revaz-Breton, L-F. Lye, S.M. Hickerson, S.M. Beverley, H. Acha-Orbea, P. Launois, N. Fasel and S. Masina (2010), “Leishmania RNA Virus controls the severity of LeishmaniasisScience 331: 775-778. PMCID:3253482.

  Commentary related to above paper published in Science:

  Scott, P. (2011), "Leishmania - A Parasitized Parasite" The New England Journal of Medicine 364:1773-74

  Olivier, M. (2011), "Culprit within a Culprit" Nature 471:173-74

210. Dobson, D.E., S. Kamhawi, P. Lawyer, S.J. Turco, S. M. Beverley, and D. L. Sacks (2010), Survival of Leishmania major in the selective sand fly vector Phlebotomus papatasi requires a specific SCG-encoded lipophosphoglycan galactosylation pattern”, PLoS Pathogens 6(11): e1001185. PMCID: PMC2978724

209.  Lye, L-F, Kang, S.O., Nosanchuk, J.D., Casadevall, A., and S.M. Beverley (2010), “Phenylalanine hydroxylase (PAH) from the lower eukaryote Leishmania major”, Molec. Biochem. Parasitol. 175: 58–67. PMCID: NIHMSID248255.

208.  Lye, L-F., Owens, K.L. , Shi, H., Murta, S.M.F., Vieira, A.C., Turco, S.J., Tschudi, C., Ullu, E., and S.M. Beverley (2010), “Retention and loss of RNA interference pathways in Trypanosomatid protozoans”, PLoS Pathogens 6: e1001161. PMCID: PMC2965760

207.  Feng, X., Feistel, T., Buffalo, C., McCormack, A., Kruvand, E., Rodriguez-Contreras, D., Akopyants, N., Umasankar, P.K., David, L., Jardim, A., Beverley, S.M., and S.M. Landfear (2010), "Remodeling of protein and mRNA expression in Leishmania mexicana induced by deletion of glucose transporter genes”, Molec. Biochem Parasitol. 175(1):39-48. PMCID: PMC2974008

206.  Thalhofer, C.J., Graff,J. W., Love-Homan, L., Hickerson, S. M., Craft, N., Beverley, S.M., and M. E. Wilson (2010), "In vivo imaging of transgenic Leishmania parasites in a live host”, Journal of Visual Experimentation 41: pii: 1980 ( PMCID in process.

205.  Madeira da Silva, L., and S.M. Beverley (2010), “Expansion of the target of rapamycin (TOR) kinase family and function in Leishmania shows that TOR3 is required for acidocalcisome biogenesis and animal infectivity” , Proc. Natl. Acad. Sci. USA 107:(26) 11965-11970. PMCID: PMC2900677

204.  Morales, M.A., R. Watanabe, M. Dacher, P. Chafey, J. Osorio y Fortéa, D. A. Scott, S. M. Beverley, G. Ommen, J. Clos, S. Hem, P. Lenormand, J-C. Rousselle, A. Namane, and G. F. Späth (2010), “Phosphoproteome dynamics reveal heat shock protein complexes specific to the Leishmania infectious stage”, Proc. Natl. Acad. Sci. USA 107: 8381-6. PMCID: PMC2889574

203.  Lamerz, A.-C., S. Damerow, B. Kleczka, M. Wiese, G. van Zandbergen, J. Lamerz, A. Wenzel, F-F. Hsu, J. Turk, S.M. Beverley and F.H. Routier (2010), “Deletion of UDP-glucose pyrophosphorylase reveals a UDP-glucose independent UDP-galactose salvage pathway in Leishmania  major”, Glycobiology 20: 872-82. PMCID: PMC2900899

202.  Waller, J.C., S. Alvarez, V. Naponelli, A. Lara-Nunez, I. K. Blaby, V. Da Silva, M.J. Ziemak, T.J. Vickers, S.M. Beverley, A.S. Edison, J.R. Rocca, J.F. Gregory III, V. de Crécy-Lagard, and A.D. Hanson (2010), “A new role for tetrahydrofolate in the metabolism of iron sulfur clusters in all domains of life”,Proc. Natl. Acad. Sci. USA 107: 10412-7. PMCID: PMC2890791

201.  Latorre-Esteves, E., O.E. Akilov, P. Rai, S.M. Beverley and T. Hasan (2010), “Monitoring the efficacy of antimicrobial photodynamic therapy in a murine model for cutaneous leishmaniasis with GFP+ Leishmania major” (2010), J. Biophotonics 3:328- 335. PMCID: PMC2876225

200. Secundino, N., N. Kimblin, N.C. Peters, P. Lawyer, A. A. Capul, S. M. Beverley, S. J. Turco, and D. Sacks (2010), “Proteophosphoglycan confers resistance of Leishmania major to midgut digestive enzymes induced by blood feeding in vector sand flies Cellular Microbiology 12: 906-918.  PMCID: PMC2891569

199.   Zhang, K. and S. M. Beverley (2010), “Phospholipid and sphingolipid metabolism in Leishmania, Molecular & Biochemical Parasitology 170:55–64. PMCID: PMC2815228

198.  Eudes, A., E.R.S. Kunji, A. Noiriel, S.M.J. Klaus, T. J. Vickers, S.M. Beverley, J. F. Gregory III, and A. D. Hanson (2010), “Identification of Transport-Critical Residues in a Folate Transporter from the FBT Family”, J. Biol. Chem. 285:2867-75. PMCID: PMC2807340

197.  Svárovská, A., T. H. Ant, V. Seblová, L. Jecná, S. M. Beverley and P. Volf (2010), “ Leishmania major Glycosylation Mutants Require Phosphoglycans (lpg2−) but Not Lipophosphoglycan (lpg1−) for Survival in Permissive Sand Fly Vectors”, PLoS Neglected Tropical Diseases 4:e580   PMCID: PMC2797086

196.  Zhang, O., M. C. Wilson, W. Xu, F-F. Hsu, J. Turk, F. M. Kuhlmann, Y. Wang, L. Soong, P. Key, S. M. Beverley, and K. Zhang (2009), “Degradation of Host Sphingomyelin is Essential for Leishmania Virulence”, PLoS Pathogens: e1000692. PMCID: PMC2784226

195.  Muleme, H.M., R.M. Reguera, A. Berard, I. Okwor, R. Azinwi, S.M. Beverley and J. E. Uzonna, (2009), “Infection with arginase deficient Leishmania major reveals a parasite number-dependent and IL-4-independent regulation of host cellular arginase activity and disease pathogenesis”, J. Immunol. 183: 8068-8076.   PMCID: PMC2800308.

194.  Okwor, I., D. Liu, S. M. Beverley and J.E Uzonna (2009), “Inoculation of killed Leishmania major into immune mice rapidly disrupts immunity to a secondary challenge via an IL-10-mediated process”, Proc. Natl. Acad. Sci. USA 106: 13951 - 13956. PMCID: PMC2729001.

193.  Tosi, L.R.O., S. M. Beverley and J. D. Damasceno (2010), “A transposon toolkit for gene transfer and mutagenesis in protozoan parasites”, Genetica 138:301–311.   PMCID:  PMC2807340.

192.  Liu, D., C. Kebaier, N. Pakpour, A.A. Capul, S. M. Beverley, P Scott and J. E. Uzonna (2009), “Leishmania major phosphoglycans influence the early host immune response by modulating dendritic cell functions”, Infection & Immunity 77: 3272-3283. PMCID: PMC2715672.

191.  Nare, B., L. A. Garraway., T. J. Vickers and S. M. Beverley (2009), “PTR1-dependent synthesis of tetrahydrobiopterin contributes to oxidant susceptibility in Leishmania major”, Current Genetics 55: 287-299. PMCID: PMC2759280.

190.  Späth, G. F., P. Schlesinger, R. Schreiber and S.M. Beverley (2009), “A novel role for Stat1 in phagosome acidification and natural host resistance to intracellular infection by Leishmania major”, PLoS Pathogens 5: e1000381.  PMCID: PMC2663844

189.   Madeira da Silva, L., K.L. Owens, S.F.M. Murta, and S.M. Beverley (2009), “Regulated expression of the Leishmania major surface virulence factor lipophosphoglycan using conditionally destabilized fusion proteins”, Proc. Natl. Acad. Sci. USA 106:.7583-7588. PMCID: PMC2678649.

188.  Zhang, K., J. D. Bangs and S.M. Beverley (2010), “Sphingolipids in Parasitic Protozoa”, in Sphingolipids as signaling and regulatory molecules, C. Chalfant and M. del Poeta (eds.), Landes Biosciences (Austin TX),  (in press). NIHMSID: 107691

187.  Gaur, U., M. Showalter, S. Hickerson, R. Dalvi, S. J. Turco, M. E. Wilson, and S. M. Beverley (2009), “Leishmania donovani lacking the Golgi GDP-Man transporter LPG2 exhibit attenuated virulence in mammalian hosts”, Exptl. Parasitol. 122: 182-191.  PMCID: PMC2720449

186.  Akopyants*, N., N. Kimblin*, N. Secondino, R. Patrick, P. Lawyer, D.E. Dobson, S.M. Beverley*, and D.L. Sacks* (2009), “Demonstration of genetic exchange during cyclical development of Leishmania in the sand fly vector”, Science 324: 265-268.  PMCID: PMC2729066   (*1st two authors contributed equally; last two authors contributed equally). (see commentary “Leishmania exploit sex”, Miles, M.A., M. Yeo, and I.L. Mauricio (2009) Science 324: 187-189).

185.  Vickers*, T.J., S.M.F. Murta*, M..A. Mandell and S.M. Beverley (2009), “The enzymes of the 10-formyl-tetrahydrofolate synthetic pathway are found exclusively in the cytosol of the trypanosomatid parasite Leishmania major”, Molec. Biochem. Parasitol. 166: 142-152. (1st two authors contributed equally).   PMCID: PMC2692634

184.  Murta*, S.M.F., T.J. Vickers*, D.A. Scott and S.M. Beverley (2009), “Methylene tetrahydrofolate dehydrogenase/cyclohydrolase and the synthesis of 10-CHO-THF are essential in Leishmania major”, Molecular Microbiology 71: 1386-1401.   PMCID: PMC2692627.   * (1st two authors contributed equally).

183.  Reguera, R.M., R. Balaña-Fouce, M. Showalter, S. Hickerson and S. M. Beverley (2009), “Leishmania major lacking arginase are polyamine auxotrophsbut retain infectivity to susceptible BALB/c mice”, Molec. Biochem. Parasitol. 165: 48-56. PMCID: PMC2735255

182.  Feng, X., D. Rodriguez-Contreras, C. Buffalo, A. Bouwer, E. Kruvand, S. M. Beverley, and S. M. Landfear (2009), “Amplification of an alternate transporter gene suppresses the avirulent phenotype of glucose transporter null mutants in Leishmania mexicana”, Molecular Microbiology 71: 369-381. PMCID: PMC2729070.

181.  Ng, L.G., A. Hsu, M.A. Mandell, C. Hoeller, P. Mrass, A. Iparraguirre, L. L. Cavanagh, S. M. Beverley, P. Scott and W. Weninger (2008), “Migratory dermal dendritic cells act as rapid sensors of protozoan parasites”, PLOS Pathogens 4: e1000222. PMCID: PMC2583051

180.  Sutterwala, S., F. F. Hsu, E. S. Sevova, K. J. Schwartz, , K. Zhang, P. Key, J. Turk, S. M. Beverley and J. D. Bangs (2008), “Developmentally Regulated Sphingolipid Synthesis in African Trypanosomes”, Molecular Microbiology 70: 281-96.  PMCID: PMC2629665

179.  Späth, G.F., M. McDowell, and Stephen M. Beverley (2008), “Leishmania major intracellular survival is not altered in SHP-1 deficient mev or CD45-/- mice”, Exptl. Parasitology 120: 275-279.  PMCID:PMC2811416

178.  Naponelli, V. A. Noiriel, M. J. Ziemak, S. Beverley, L-F. Lye, A. M. Plume, J. R. Botella, K. Loizeau, S. Ravanel, F. Rébeillé, V. de Crécy, and A. D. Hanson (2008), “Phylogenomic and functional analysis of pterin-4a-carbinolamine dehydratase family (COG2154) proteins in plants and microorganisms”, Plant Physiology 146: 1515-1527.   PMCID: PMC2287330

177.  Scott, D. A., S. M. Hickerson, T. J. Vickers, and S. M. Beverley (2008), “The role of the mitochondrial glycine cleavage complex in the metabolism and virulence of the protozoan parasite Leishmania major”, J. Biol. Chem. 283: 155-165.

176.  Capul, A.A., S. Hickerson, T. Barron, S. J. Turco, and S. M. Beverley (2007), “Comparisons of mutants lacking the Golgi UDP-Galactose or GDP-Mannose transporters establish that phosphoglycans are important for promastigote but not amastigote virulence in Leishmania major”, Infection & Immunity 75: 4629-4637.  PMCID: PMC1951182

175.  Hsu, F-F, Turk, J., Zhang, K. and S. M. Beverley (2007), “Characterization of Inositol Phosphorylceramides from Leishmania major by tandem mass spectrometry with electrospray ionization”, J. Am. Soc. Mass Spectrometry 18: 1591-1604.  PMCID: PMC2065762

174.  Buck, G., M. Berriman, J. Donelson, N. El-Sayed, J. Kissinger, L. Simpson, A. Tait, M. Teixera, and S. M. Beverley (2007), “Pathogenomics of Trypanosomatid parasites”, NIHGRI White Paper, .

173.  Capul, A.A., T. Barron, D. E. Dobson, S. J. Turco, and S. M. Beverley (2007), “Two functionally divergent UDP-Gal nucleotide-sugar transporters participate in phosphoglycan synthesis in Leishmania major”, J. Biological Chemistry 282: 14006-14017. PMCID: PMC2807729

172.  Zhang, K., J. M. Pompey, F-F Hsu, P. Key, P. Bandhuvula, J.D. Saba, J. Turk, and S.M. Beverley (2007), “Redirection of sphingolipid metabolism towards ethanolamine synthesis in Leishmania”, EMBO J. 26:1094-1104.

171.  Myskova, J., M. Svobodova, M., S.M. Beverley, and P. Volf (2007), “An LPG-independent adherence paradigm for Leishmania – sand fly interactions in permissive vectors”, Microbes & Infection 9:317-324. 

170. Vickers, T.J., G. Orsomando, R. D. de la Garza, D. A. Scott, S. O. Kang, A.D. Hanson and S. M. Beverley (2006), “Biochemical and genetic analysis of methylenetetrahydrofolate reductase in Leishmania metabolism and virulence”, J. Biological Chemistry 281:  38150–38158.

169.  Dobson, D.E., L. D. Scholtes, P. J. Myler, S.J. Turco, and S. M. Beverley (2006), “Telomeric and internal clusters of the expanded SCG gene family associated with developmental and species-specific LPG modifications in Leishmania major”, Molecular & Biochemical Parasitology 146: 231-241.

168.  Goswami, M., D. E. Dobson, S. M. Beverley & S. J. Turco (2006), “Demonstration by Heterologous Expression that the Leishmania SCA1 Gene encodes an ArabinopyranosyltransferaseGlycobiology 16:230-236.

167.  Kébaïer, C., J.E. Uzonna, S.M. Beverley, and P. Scott (2005), “The presence of persistent attenuated Leishmania major parasites is not sufficient to provide protective immunity in C57BL/6 mice”, Infection & Immunity 74: 77-80.

166.  Schüttelkopf, A.W., L. W. Hardy S. M. Beverley and W.N. Hunter (2005), “Structures of Leishmania major pteridine reductase complexes reveal the active site features important for ligand binding and to guide structure-based inhibitor design”,  J. Mol. Biol. 352:  105-116.

165. Ivens, A.C., (50+ authors, including S.M. Beverley), & P. J. Myler, “Genome sequence of the kinetoplastid parasite Leishmania major” (2005), Science 309:436-442.

164.  Casagrande, L., J.C. Ruiz, S.M. Beverley, & A. K. Cruz (2005), “Identification of DNA fragments which increase mitotic stability of linear episomal DNAs in Leishmania major“,  International Journal for Parasitology 35: 973-980.

163.  Beverley, S. M., K. L. Owens, M. Showalter, C. L. Griffith, T. L. Doering, V. C. Jones, and M. R. McNeil (2005), “Identification of eukaryotic UDP-galactopyranose mutase (UGM/GLF) in microbial and metazoal pathogens”, Eukaryotic Cell 4:1147-1154.

162. Segawa, H., R. Soares, M. Kawakita, S.M. Beverley and S. J. Turco (2005), “Reconstitution of GDP-Man Transport Activity with Purified Leishmania LPG2 Protein in Proteoliposomes”, J. Biol. Chem. 280:  2028 -2035.

161.  Zhang, K., F-F. Hsu, D. A. Scott, R. Docampo, J. Turk, and S. M. Beverley (2005), “Salvage and remodeling of host sphingolipids in Leishmania amastigote survival and acidocalcisome biogenesis”, Molecular Microbiology 55:1566-1578.

160.  Beverley, S.M. & D.E. Dobson (2004), “Flypaper for parasites”, Cell 119:311-312. 

159.  Boulanger, N., C. Lowenberger, P. Volf, R. Ursic, L. Sigutova, L. Sabatier, M. Svobodova, S.M. Beverley, G. Späth, R. Brun,  B. Pesson, and P. Bulet (2004), “Characterization of a defensin from the sand fly Phlebotomus duboscqiinduced by challenge with bacteria or the protozoan parasite Leishmania major, Infection & Immunity 72: 7140-6.

158.   Zaph, C., J. Uzonna, S.M. Beverley, and P. Scott (2004), “Central memory T cells mediate long-term immunity to Leishmania major in the absence of persistent parasites”, Nature Medicine 10:1104-1109.  (see commentary:  Seder and Sacks “Memory may not need reminding”, Nature Medicine 10: 1045-1047).

157.  Späth, G. L-F. Lye, H. Segawa, S. J. Turco, and S. M. Beverley (2004), “Identification of a compensatory mutant (lpg2-REV) in Leishmania major able to survive as amastigotes within macrophages without LPG2-dependent glycoconjugates, and its significance to virulence and immunization strategies”, Infection & Immunity 72:3622-3627.

156.  Akopyants, N.S., R. S. Matlib, B. H. Brownstein, G. D. Stormo, and S. M. Beverley (2004), “Expression profiling using a random genomic DNA microarray identifies differentially expressed genes associated with three major developmental stages of the protozoan parasite Leishmania major”, Molec. Biochem. Parasitol. 136:71-86.

155.  Zhang, K., T. Barron, S.J. Turco, and S.M. Beverley (2004), “The LPG1 family of Leishmania major”, Molec. Biochem. Parasitol. 136:11-23.

154.  Uzonna, J., G. Späth, S. M. Beverley, and P. Scott (2004), “Vaccination with phosphoglycan-deficient lpg2- knockout Leishmania major protects highly susceptible mice from virulent challenge”, J. Immunology 172:  3793-7.

153.  Duncan, R., P. Salotra, N. Goyal, N. Akopyants, S.M. Beverley, and H. Nakhasi (2004), “The application of gene expression microarray technology to Kinetoplastid research”, Current Molecular Medicine 4: 611-621.

152.   Zhang, K., M. Showalter, J. Revollo, F-F. Hsu, J. Turk, and S.M. Beverley (2003), "Sphingolipids are essential for differentiation but not growth in Leishmania”, EMBO J. 22: 6016-26.

151.  Zufferey, R., S. Allen, T. Barron, D.R. Sullivan P.W. Denny, I.C. Almeida, D.F. Smith, S. J. Turco, M.A.J. Ferguson, and S.M. Beverley (2003). “Ether phospholipids and glycosylinositolphospholipids (GIPLs) are not required for amastigote virulence nor for inhibition of macrophage activation by Leishmania major”, J. Biol. Chem. 278:  44708-18.

150.  Späth, G., L-F. Lye, H. Segawa, D. L. Sacks, S. J. Turco, and S. M. Beverley (2003), “Persistence without pathology in phosphoglycan-deficient Leishmania major”, Science 301: 1241-3.

149.  Späth, G., L. A. Garraway, S. J. Turco, and S. M. Beverley (2003), “The role(s) of lipophosphoglycan (LPG) in the establishment of Leishmania major infections in mammalian hosts”, Proc. Natl. Acad. Sci. U.S.A. 100:  9536-41.

148.  Marchini, J.F.M., A.K. Cruz, S.M. Beverley, and L.R.O. Tosi (2003), “The H region HTBF gene mediates terbinafine resistance in Leishmania major”, Molec. Biochem. Parasitol. 131:  77-81.

147.  Goyard, S. H. Segawa, J. Gordon, M. Showalter, R. Duncan, S. J. Turco, and S. M. Beverley (2003), “An in vitro system for differentiation and genetic studies of Leishmania donovani phosphoglycans”, Molec. Biochem. Parasitol. 130:  31-42.

146.  Dobson, D.E., B. J. Mengeling, S. Cilmi, S. Hickerson, S. J. Turco and S. M. Beverley (2003), “Identification genes encoding the arabinosyl transferases (SCA) mediating developmental modifications of lipophosphoglycan (LPG) required for sand fly transmission of Leishmania major”, J. Biol. Chem. 278:  28840-28848.

145.  Coelho, A.C., S.M. Beverley, and P.C. Cotrim (2003), “Functional genetic identification of PRP1, an ABC transporter superfamily member conferring pentamidine resistance in Leishmania”, Molec. Biochem. Parasitol. 130:  83-90.

144.   Robinson, K.A., S. Goyard, and S. M. Beverley (2004), “in vitro shuttle mutagenesis using engineered Mariner transposons”, in Methods in Molecular BiologyParasite Genomics Protocols, Sarah Melville, Editor; Humana Press, 270:  299-318.

143.  Robinson, K.A. and S. M. Beverley (2003), “Improved methods for transient transfections and tests of RNAi approaches in the protozoan parasite Leishmania”, Molec. Biochem. Parasitol. 128:  217-228.

142.  Atreya, C.E., E. F. Johnson, J.J. Irwin, A. Dow, K. M. Massimine, I. Coppens, V. Stempliuk, S.M. Beverley, K.A. Joiner, B. K.Shoichet, and K. S. Anderson (2003), “A Molecular Docking Strategy Identifies Eosin B as a Non-Active Site Inhibitor of Protozoal Bifunctional Thymidylate Synthase-Dihydrofolate Reductase”, J. Biological Chemistry 278: 14092-14100.

141.  Dobson, D.E., L. Scholtes, K. Valdez, D. R. Sullivan, B. J. Mengeling, S. Cilmi, S. J. Turco, and S. M. Beverley (2003), “Functional Identification of Galactosyltransferases (SCGs) required for species-specific modifications of the lipophosphoglycan (LPG) adhesin controlling Leishmania major-sand fly interactions”, J. Biological Chemistry 278: 15523-15531.

140.  Beverley, S.M. (2003), “Trypanosomatid protozoan parasite genetics comes of age:  Protozomics!”, Nature Reviews Genetics 4:11-19.

139.  Gao, L-Y., R. Groger, J. Cox, S.M. Beverley, E. Lawson, and E. J. Brown (2003), “Transposon mutagenesis of Mycobacterium marinum reveals a link between pigmentation and intracellular survival”, Infection & Immunity 71: 922-29.

138.  Amaral, V.F., A. Teva, M.P. Oliveira-Neto, A.J. Silva, M.S. Pereira, E. Cupolillo, R. Porrozzi, S.G. Cotinho, C. Pirmez, S.M. Beverley and G. Grimaldi Jr. (2002), “Study of the safety, immunogenicity and efficacy of attenuated and killed Leishmania major vaccines in a Rhesus monkey (Macaca mulatta) model of the human disease”, Memorias do Instituto Oswaldo Cruz 97: 1041-1048.

137.  Lye, L-F., M. Cunningham, and S.M. Beverley (2002), “Characterization of quinonoid-Dihydropteridine Reductase (QDPR) from the lower eukaryote Leishmania major”, J. Biol. Chem. 277:  38245-38253.

136.  Descoteaux, A., H. A. Avila, K. Zhang, S. J. Turco, and S.M. Beverley (2002), “Leishmania LPG3 encodes a GRP94 homolog required for phosphoglycan synthesis implicated in parasite virulence but not viability”, EMBO J. 21:  1-12.

135.  Breitling, R., S. Klingner, R. Pietrucha, A. Geyer, G. Ehrlich, N. Callewaert, A. Müller, K-H Gührs, R. Contreras, S.M. Beverley, and K. Alexandrov (2002), “Kinetoplastida as a novel platform for protein research and production”, Protein Expression & Purification 25:  209-18.

134.  Myler, P.J., S.M. Beverley, A.K. Cruz, D.E. Dobson, A.C. Ivens, P.D. McDonagh, R. Madhubala, S. Martinez-Calvillo, J.C. Ruiz, A. Saxena, E. Sisk, S.M. Sunkin, E. Worthey, S. Yan, and K.D. Stuart (2001), “The Leishmania genome project:  new insights into gene organization and function”, Med. Microbiol. Immunol. 190:  9-12.

133.  Goyard, S., L.R.O. Tosi, J. Gouzova, J. Majors, and S.M. Beverley (2001), “New Mos1 mariner derivatives and transposition assays suitable for the recovery of gene fusions in vivo and in vitro”, Gene 280:  97-105.

132.  Späth, G.F. and S. M. Beverley (2001), “An LPG-independent method for isolation of infective Leishmania metacyclic promastigotes by density gradient centrifugation”, Exptl. Parasitol. 99:  97-103.

131.  Beverley, S.M. (2003), “Genetic and genomic approaches to the analysis of Leishmania virulence”, in Molecular & Medical Parasitology, J. Marr, T. Nilsen and R. Komuniecki, editors, Academic Press, New York, pages 111-122.

130.  Beverley, S.M., N.S. Akopyants, S. Goyard, R.S. Matlib, J.L. Gordon, B.H. Brownstein, G.D. Stormo, E.N. Bukanova, C.T. Hott, F. Li, S. MacMillan, J.N. Muo, L.A. Schwertman, M.R. Smeds and Y. Wang (2002), “Putting the Leishmania genome to work:  functional genomics by transposon trapping and expression profiling”, Philosophical Transactions B of the Royal Society:  Biological Sciences 357:  47-53.

129.  Selva, E.M., K. Hong, G-H. Baeg, S.M. Beverley, S.J. Turco, N. Perrimon and U. Häcker (2001),“Dual role of the fringe connection gene in both wingless and fringe-dependent signaling events”.  Nature Cell Biol. 3:  809-815.

128.  Gourley, D.G., A.W. Schüttelkopf, G.A. Leonard, J. Luba, L.W. Hardy, S.M. Beverley and W.N. Hunter (2001), “Structure and mechanism of Leishmania pteridine reductase correlate pterin metabolism with antifolate drug resistanceNature Structural Biol. 8:  521-525.

127.  Sunkin, S.M., P. McDonagh, M.L. Cunningham, S.M. Beverley, K. Stuart and P.J. Myler (2001), “Conservation of the LD1 region in Leishmania includes DNA implicated in LD1 amplification”, Molec. Biochem. Parasitol. 113:  315-321.

126.  Cunningham, M.L, R. Titus, S.J. Turco and S.M. Beverley (2001), “Regulation of differentiation to the infective stage of the protozoan parasite Leishmania by tetrahydrobiopterin”, Science 292:  285-7.

125.  Turco, S.J., G.F. Späth and S.M. Beverley (2001), “Is Lipophosphoglycan (LPG) a Virulence Factor?  A surprising diversity between Leishmania species”, Trends in Parasitology 17:  223-226.

124.  Cunningham, M.L. and S.M. Beverley (2001), “Pteridine salvage throughout the Leishmania infectious cycle and the implications for antifolate chemotherapy”, Molec. Biochem. Parasitol. 113:  199-213.

123.  Akopyants, N.S., S.W. Clifton, J. Martin, D. Pape, T. Wylie, L. Li, J.C. Kissinger, D.S. Roos,  and S.M. Beverley (2001), “A Survey of the Leishmania major Friedlin strain VI genome by Shotgun Sequencing: A Resource for DNA Microarrays and expression profiling”, Molec. Biochem. Parasitol. 113:  337-340.

122. Streit, J.A., T.J. Recker, F. Gueiros-Filho, S.M. Beverley, and M.E. Wilson (2001), “Protective immunity against the protozoan Leishmania chagasi is induced by subclinical cutaneous infectious with virulent but not avirulent organisms”, J. Immunol.  166:  1921-9.

121.  Gehring, A.M., J.R. Nodwell, S.M. Beverley, and R.M. Losick (2000), “Genome-wide insertional mutagenesis in Streptomyces coelicolor identifies additional genes involved in morphological differentiation”, Proc. Natl. Acad. Sci. USA 97:  9642-7.

120. Coates, C.J., N. Jasinskiene, D. Morgan, L.R.O. Tosi, S.M. Beverley, and A.A. James (2000) “Purified mariner (Mos1) transposase catalyzes the integration of marked elements into the germ-line of the yellow fever mosquito, Aedes aegypti”.  Insect Biochemistry and Molecular Biology 30:  1003-1008.

119. Späth, G.F., L. Epstein, B. Leader, S.M. Singer, H.A. Avila, S.J. Turco and S.M. Beverley (2000), “Lipophosphoglycan (LPG) is a virulence factor distinct from related glycoconjugates in the protozoan parasite Leishmania major”, Proc. Natl. Acad. Sci. USA 97:  9258-9263.

118. Ben Mamoun, C., I.Y. Gluzman, S.M. Beverley and D.E. Goldberg (2000), “Transposition of the Drosophila element mariner within the human malaria parasite Plasmodium falciparum”.  Molec. Biochem. Parasitol. 110:  405-408.

117. Carrillo, M.B., W. Gao, W. M. Herrera, J. Moore, J. Alroy, S.M. Beverley, and M.A. Pereira (2000), “Heterologous expression of Trypanosoma cruzi trans-sialidase in Leishmania enhances virulence”, Infection & Immunity 68:  2728-34.

116. Goyard, S. and S.M. Beverley (2000), “Blasticidin S resistance:  a new independent dominant selectable marker for stable transfection of Leishmania”, Molec. Biochem. Parasitol. 108:  249-252.

115. Tosi, L.R.O, and S. M. Beverley (2000), “cis and trans factors affecting Mos1 mariner evolution and transposition in vitro, and its application to functional genomics”, Nucleic Acids Res. 28:  784-790.

114.  Hong, K., D. Ma, S.M. Beverley, and S.J. Turco (2000), “The Leishmania GDP-Mannose transporter is an autonomous, multi-specific, hexameric complex of LPG2 subunits”, Biochemistry 39: 2013-2022.

113. Sacks, D.L., G. Modi, E. Rowton, G. Späth, L. Epstein, S.J. Turco and S.M. Beverley (2000), “The role of phosphoglycans in Leishmania - sand fly interactions”, Proc. Natl. Acad. Sci. U. S. A. 97:  406-11.

112. Chakkalath, H.R., A.A. Siddiqui, A.H. Shankar, D.E. Dobson, S.M. Beverley, and R.G. Titus (2000), "Priming of a b-galactosidase (bGAL)-specific type 1 response in BALB/c mice infected with bGAL-transfected Leishmania major", Infection & Immunity 68: 809-814.

111.  Brodskyn, C., S.M. Beverley, and R.G. Titus (2000), “Virulent or avirulent (dhfr-ts-) Leishmania major elicit predominantly a type-1 cytokine response by human cells in vitro”, Clinical and Experimental Immunology 119:  299-304.

110.  Cotrim, P.C., L.K. Garrity, and S.M. Beverley (1999), “Isolation of genes mediating resistance to inhibitors of nucleoside and ergosterol metabolism in Leishmania by over-expression/selection”, J. Biol. Chem. 274:  37723-37730.

109.  Clayton, C, S. Ha, L. Rusché, C. Hartmann, and S.M. Beverley (2000), “Tests of heterologous promoters and intergenic regions in Leishmania majorMolec. Biochem. Parasitol. 105: 163-167.

108.  Lemley, C., S. Yan, V.S. Dole, R. Madhubala, M.L. Cunningham, S.M. Beverley, P.J. Myler, and K.D. Stuart (1999),  “The Leishmania donovani LD1 locus gene ORFG encodes a biopterin transporter (BT1)Molec. Biochem. Parasitol. 104: 93-105.

107.  Cormack, B., B.T. Rouse, and S.M. Beverley (1999), “Host-microbe interactions:  fungi/viruses/parasites.  Editorial Overview:  The emergence of protozoan microbiology”, Current Opinions in Microbiology 2: 343-347.

106.  Gourley, D., J. Luba, L.W. Hardy, S.M. Beverley, and W.N. Hunter (1999), “Crystallization of recombinant Leishmania major Pteridine Reductase 1 (PTR1)”, Acta Crystallographica D Biol Crystallogr. 55: 1608-10.

105.  Ben Mamoun, C., I.Y. Gluzman, S. Goyard, S.M. Beverley, and D.E. Goldberg (1999), “A set of independent selectable markers for transfection of the human malaria parasite Plasmodium falciparum”, Proc. Natl. Acad. Sci. USA 96: 8716-8720.

104.  Veras, P.S.T., C.I. Brodskyn, F. Balestieri, L.A.R. de Freitas, A.P.S. Ramos, A.R.P. Queiroz, A. Barral, S.M. Beverley and M. Barral-Netto (1999), “A dhfr-ts- Leishmania major knockout mutant cross-protects against Leishmania amazonensis”, Memorias do Oswaldo Cruz 94: 491-496.

103.  Wang, Y., K. Dimitrov, L.K. Garrity, S. Sazer, and S.M. Beverley (1998), “Stage-specific activity of the Leishmania major CRK3 kinase and functional rescue of a Schizosaccharomyces pombe cdc2 mutant”, Mol. Biochem. Parasitol. 96: 139-150.

102. Vasudevan, G., N.S. Carter, M.E. Drew, S.M. Beverley, M.A. Sanchez, A. Seyfang, B. Ullman and S. Landfear (1998), “Cloning of Leishmania nucleoside transporter genes by rescue of a transport-deficient mutant”, Proc. Natl. Acad. Sci. USA 95: 9873-9878.

101. Clayton, C., M. Adams, R. Almeida, T. Baltz, M. Barrett, P. Bastien, S. Belli, S.M. Beverley, N. Biteau, J. Blackwell, C. Blaineau, M. Boshart, F. Bringaud, C. Clayton, A. Cruz, W. Degrave, J. Donelson, N. El-Sayed, G. Fu, K. Ersfeld, W. Gibson, K. Gull, A. Ivens, J. Kelly, D. Lawson, J. Lebowitz, P. Majiwa, K. Matthews, S. Melville, G. Merlin, P. Michels, P. Myler, A. Norrish, F. Opperdoes, B. Papadopoulou, M. Parsons, T. Seebeck, D. Smith, K. Stuart, M. Turner, E. Ullu, and L. Vanhamme (1998), “Genetic nomenclature for Trypanosoma and Leishmania”, Mol. Biochem. Parasitol. 97: 221-224.

100. Descoteaux, A., B.J. Mengeling, S.M. Beverley, and S.J. Turco (1998), “Leishmania donovani has distinct mannosylphosphoryltransferases for the initiation and elongation phases of lipophosphoglycan repeating unit biosynthesis”.  Mol. Biochem. Parasitol. 94: 27-40.

99. Luba, J.L., B. Nare, P-H. Liang, K.S. Anderson, S.M. Beverley, and L.W. Hardy (1998), “Leishmania major pteridine reductase 1 (PTR1) belongs to the short chain dehydrogenase family:  stereochemical and kinetic evidence”, Biochemistry 37: 4093-4104.

98. Beverley, S.M., and S.J. Turco (1998), “LPG and the identification of virulence genes in the protozoan parasite Leishmania”, Trends in Microbiology 6: 35-40.

97. Hardy, L.W., W. Matthews, B. Nare, and S.M. Beverley (1997), “Biochemical and genetic tests for inhibitors of Leishmania pteridine pathwaysExperimental Parasitology 87: 157-169.

96. Mengeling, B.J., S.M. Beverley, and S.J. Turco (1997), “Designing glycoconjugate biosynthesis for an insidious intent:  phosphoglycan assembly in Leishmania parasites”.  Glycobiology 7: 873-880.

95. Gueiros-Filho, F.J., and S.M. Beverley (1997), “Trans-kingdom transposition:  mobilization of the Drosophila element mariner in the protozoan Leishmania”, Science 276: 1716-1719.

94. Garraway, L.A., L.R.O. Tosi, Y. Wang, J.B. Moore, D.E. Dobson, and S.M. Beverley (1997), “Insertional mutagenesis using a modified in vitro Ty1 transposition system”, Gene 198: 27-35.

93.  Nare, B., L. Hardy, and S.M. Beverley (1997), “New approaches to Leishmania chemotherapy: Pteridine Reductase 1 (PTR1) as a target and modulator of antifolate sensitivity”, in Molecular Basis of Drug Design and Resistance, Coombs, G.H. and Croft, S.L. (eds), Parasitology 114: S102-S110, Cambridge University Press.

92. Nare, B., L. Hardy, and S.M. Beverley (1997), "The roles of Pteridine Reductase 1 (PTR1) and Dihydrofolate Reductase-Thymidylate Synthase (DHFR-TS) in pteridine metabolism in Leishmania", J. Biol. Chem. 272: 13883-13891.

91. Garcia, M.R., S. Graham, R.A. Harris, S.M. Beverley, and P.M. Kaye (1997), “Epitope cleavage by Leishmania endopeptidase(s) limits the efficiency of the ‘exogenous’ pathway of MHC class I associated antigen presentation”.  Eur.  J. Immunol. 27: 1005-1013.

90. Tosi, L.R.O., L. Casagrande, S.M. Beverley, and A.K. Cruz (1997), “Physical mapping across the dihydrofolate reductase-thymidylate synthase chromosome of Leishmania major”. Parasitology 114: 521-530.

89. Racoosin, E.L., and S.M. Beverley (1997), “Leishmania major:  Promastigotes induce expression of a subset of chemokine genes in murine macrophages”.  Experimental Parasitology 85: 283-295.

88.  Beverley, S.M. (1996), “Hijacking the cell:  parasites in the driver’s seat”.  Cell 87: 787-789.

87.  Ma, D., D. Russell, S.M. Beverley, and S.J. Turco (1997), "Golgi GDP-mannose uptake requires Leishmania LPG2: a member of a eukaryotic family of potential nucleotide-sugar transporters".  J. Biol. Chem. 272: 3799-3805.

86.  Flaspohler, J.A., W.L. Rickoll, S.M. Beverley, and M. Parsons (1997), “Functional identification of a Leishmania gene related to the peroxin 2 gene reveals common ancestry of glycosomes and peroxisomes”.  Mol. Cell. Biol.17: 1093-1101.

85.  Beverley, S.M. (1995), “Identification of Leishmania genes by functional complementation:  application to drug resistance and virulence”.  Memorias do Instituto Oswaldo Cruz 90(I): 12-14.

84.  Turco, S.J., and S.M. Beverley (1996) “A genetic analysis of the biosynthetic pathway of the Leishmania virulence factor LPG”, Trypanosomiasis and Leishmaniasis (G. Hide, J.C. Mottram, G.H. Coombs, P.H. Holmes, eds), CAB International, Glasgow, p. 79-88.

83.  Ha, D.S., J.K. Schwarz, S.J. Turco, and S.M. Beverley (1996), "Use of the green fluorescent protein as a marker in transfected Leishmania ".  Mol. Biochem. Parasitol. 77: 57-64.

82.  Beverley, S.M., and S.J. Turco (1995), "Identification of genes mediating lipophosphoglycan (LPG) biosynthesis by functional complementation of Leishmania donovani mutants", Annals Trop. Medicine & Parasitology 89: s11-18.

81.  Ma, D., S.M. Beverley, and S.J. Turco (1996), “Leishmania donovani possess a NADPH-dependent glyceryl ether monooxygenase”.  Biochem. Biophys. Res. Commun. 227: 885-889.

80.  Gueiros-Filho, F.J., and S.M. Beverley (1996), "Selection against Dihydrofolate Reductase-Thymidylate Synthase (DHFR-TS) as a probe of genetic alterations in Leishmania".  Mol. Cell. Biol. 16: 5655-5663.

79.  Descoteaux, A., L. Ya, S.J. Turco, and S.M. Beverley (1995), "A specialized pathway affecting virulence glycoconjugates in Leishmania".  Science 269: 1869-1872.

78.  Cupolillo, E., G. Grimaldi Jr., H. Momen, and S.M. Beverley (1995), "Intergenic Region Typing (IRT):  a rapid molecular approach to the characterization and evolution of Leishmania", Molec. Biochem. Parasitol. 73: 145-155.

77.  Titus, R.G., F.J. Gueiros-Filho, L.A.R de Freitas, and S.M. Beverley (1995), "Development of safe live Leishmania vaccine lines by gene replacement", Proc. Natl. Acad. Sci. USA 92: 10267-10271.

76.  Callahan, H.L., W.L. Roberts, P.M. Rainey, and S.M. Beverley (1994), "The PGPA gene of Leishmania major mediates antimony (SbIII) resistance by decreasing influx and not by increasing efflux", Mol. Biochem. Parasitol. 68:145-150.

75.  Bello, A.R., B. Nare, D. Freedman, L. Hardy, and S.M. Beverley (1994), "PTR1:  a reductase mediating salvage of oxidized pteridines and methotrexate-resistance in the protozoan Leishmania major", Proc. Natl. Acad. Sci. USA 91: 11442-11446.

74.  Turco, S.J., A. Descoteaux, K. Ryan, L.A. Garraway, and S.M. Beverley (1994), "Isolation of virulence genes directing GPI synthesis by functional complementation of Leishmania", Brazilian J. Med. Biol. Res. 27: 133-138.

73.  Pimenta, P.F.P., E.M.B. Saraiva, E. Rowton, G.B. Modi, L.A. Garraway, S.M. Beverley, S.J. Turco, and D.L. Sacks (1994), "Evidence that the vectorial competence of phlebotomine sand flies for different species of Leishmania is controlled by structural polymorphisms in the surface lipophosphoglycan".  Proc. Natl. Acad. Sci. USA 91: 9155-9159.

72. Gueiros-Filho, F.J., and S.M. Beverley (1994), "On the introduction of genetically modified Leishmania outside the laboratory", Exp. Parasitol.78: 425-428.

71. Fernandes, A.P., K. Nelson, and S.M. Beverley (1993), "Evolution of nuclear ribosomal RNAs in kinetoplastid protozoa:  perspectives on the age and origins of parasitism", Proc. Natl. Acad. Sci. USA 90: 11608-11612.

70. Freedman, D.F., and S.M. Beverley (1993), "Two additional independent markers for transfection of Leishmania.  Mol. Biochem. Parasitology 62: 37-44.

69. Descoteaux, A., L.A. Garraway, K.A. Ryan, L.K. Garrity, S.J. Turco, and S.M. Beverley (1994), "Functional complementation of virulence genes in the protozoan parasite Leishmania", Methods in Molecular Genetics, K.W. Adolph ed., Vol 3, pp. 22-48.

68. Ryan, K.A., L.A. Garraway, A. Descoteaux, S.J. Turco, and S.M. Beverley (1993), "Identification of virulence genes directing surface GPI biosynthesis in protozoan parasites".  Proc. Natl. Acad. Sci. USA 90: 8609-8613.

67. Medina-Acosta, E., S.M. Beverley, and D.G. Russell (1993).  "Evolution and expression of the Leishmania surface protease (gp63) gene locus". Infectious Agents and Disease 2: 25-34.

66. Kaye, P.M., C.M. Coburn, M. McCrossan, and S.M. Beverley (1993).  "Antigens targeted to the Leishmania phagolysosome are processed for CD4+ T-cell recognition". Eur. J. Immunol. 23: 2311-2319.

65. Ryan, K.A., S. Dasgupta, and S.M. Beverley, (1993), "Shuttle cosmid vectors for the trypanosomatid parasite Leishmania”, Gene 131: 145-50.

64. Garber, D.A., S.M. Beverley, and D.M. Coen (1993), "Demonstration of circularization of Herpes Simplex virus DNA following infection using pulsed field electrophoresis". Virology 197: 459-462.

63. LeBowitz, J.H., H.Q. Smith., L. Rusché, and S.M. Beverley (1993).  "Coupling of poly(A) site selection and trans-splicing in Leishmania", Genes & Development 7: 996-1007.

62. Callahan, H.L., and S.M. Beverley (1992).  "A member of the aldoketo-reductase family confers methotrexate resistance in Leishmania".  J. Biol. Chem. 267: 24165-24168.

61. Uliana, S.R.B., K. Nelson, S.M. Beverley, E.P. Camargo, and L.M. Floeter-Winter (1994), "Discrimination amongst Leishmania by PCR amplification and hybridization with SSU rRNA-derived oligonucleotides." J. Eukaryotic Microbiology 41: 324-330.

60. López, J.A., J.H. LeBowitz, S.M. Beverley, H-G. Rammensee, and P. Overath (1992).  "Leishmania mexicana promastigotes induce cytotoxic T lymphocytes in vivo that do not recognize infected macrophages".  Eur. J. Immunol. 23: 217-223.

59. Cruz, A.K., R. Titus, and S.M. Beverley (1993).  "Plasticity in chromosome number enables testing of essential genes in Leishmania by targeting." Proc. Natl. Acad. Sci. USA 90: 1599-1602.

58. Wilson, K., S.M. Beverley, and B. Ullman (1992),  “Stable amplification of a linear extrachromosomal DNA in mycophenolic acid-resistant Leishmania donovani”.  Mol. Biochem. Parasitol. 55: 197-206.

57. Hanson, S., S.M. Beverley, W. Wagner, and B. Ullman (1992), “Unstable Amplification of two extrachromosomal elements in a-difluoromethylornithine-resistant Leishmania donovani.”  Mol. Cell. Biol 12: 5499-5507.

56. Briones, M.R.S., K. Nelson, S.M. Beverley, H.T. Affonso, E.P. Camargo, and L.M. Floeter-Winter (1992), "Leishmania tarentolae taxonomic relatedness inferred from phylogenetic analysis of small subunit ribosomal RNA genes", Mol. Biochem. Parasitol. 53: 121-128.

55. LeBowitz, J.H., A. Cruz, and S.M. Beverley (1992), "Thymidine kinase as a negative selectable marker in Leishmania major”, Molec. Biochem. Parasitol. 51: 321-326.

54. Cruz, A.C., C.M. Coburn, and S.M. Beverley. (1991), “Double targeted gene replacement in Leishmania major”Memorias do Instituto Oswaldo Cruz, Vol. 86 Suppl I, 9-10.

53. Beverley, S.M, and C.E. Clayton (1993), “Transfection of Leishmania and Trypanosoma brucei by electroporation”.  In: Hyde JE, ed.  Protocols in Molecular Parasitology, Methods in Molecular Biology Vol 21, New Jersey: Humana Press, p. 333-348.

52. Callahan, H.L., and S.M. Beverley (1991), "Heavy metal resistance:  a new role for P-glycoproteins in Leishmania", J. Biol. Chem. 266: 18427-18430.

51. Cruz, A., C.M. Coburn, and S.M. Beverley (1991), "Double targeted gene replacement for creating null mutants", Proc. Natl. Acad. Sci. USA 88: 7170-7174.

50. McMahon-Pratt, D., Y. Traub-Cseko, K. Lohman, D.D. Rogers, and S.M. Beverley (1992), "Loss of the GP46/M-2 surface membrane glycoprotein gene family in the Leishmania braziliensis complex", Mol. Biochem. Parasitol. 50: 151-160.

49. LeBowitz, J.H., C.M. Coburn, and S.M. Beverley (1991), "Simultaneous transient expression assays adapted for the trypanosomatid parasite Leishmania using ß-galactosidase and ß-glucuronidase as reporter enzymes", Gene 103: 119-123.

48. Beverley, S.M., "Gene amplification in Leishmania" (1991), Annu. Rev. Microb. 45: 417-44.

47. Coburn, C.M., K. Otteman, T.B. McNeely, S.J. Turco, and S.M. Beverley (1991), "Stable DNA Transfection of a wide range of trypanosomatids", Mol. Biochem. Parasitol. 46: 169-179.

46. Panton, L.J., R.B. Tesh, K.C. Nadeau, and S.M. Beverley (1991), "A test for genetic exchange in mixed infections of Leishmania major in the sand fly Phlebotomus papatasi", J. Protozoology 38: 224-228.

45. Cruz, A., and S.M. Beverley (1990), "Gene replacement in parasitic protozoa", Nature 348: 171-4.

44. LeBowitz, J.H., C.M. Coburn, D. McMahon-Pratt, and S.M. Beverley (1990), "Development of a stable Leishmania expression vector and application to the study of parasite surface antigen genes", Proc. Natl. Acad. Sci. USA 87: 9736-40.

43. Beverley, S.M., C.M. Coburn, and G.M. Kapler (1991), "High-efficiency stable DNA transformation of the human parasite Leishmania major", The Biology of Parasitism, C.C. Wang, Ed., American Society for the Advancement of Science, p. 139-146.

42. Nelson,K., G. Alonso, P.J. Langer, and S.M. Beverley (1990), “Sequence of the dihydrofolate reductase-thymidylate synthase gene of Leishmania amazonensis”.  Nucleic Acids Research 19: 2819 (for the record).

41. Kapler, G.M., K. Zhang, and S.M. Beverley (1990), "Nuclease mapping and DNA sequence analysis of transcripts from the dihydrofolate reductase-thymidylate synthase (R) region of Leishmania major", Nucleic Acids Research 18: 6399-6408.

40.  Swafford, J.R., S.M. Beverley, C.C. Kan, and J.P. Caulfield (1990), "Distribution of dihydrofolate reductase-thymidylate synthase polypeptide in methotrexate resistant and wild-type Leishmania major:  Evidence for cytoplasmic distribution despite a hydrophilic leader sequence", Proceedings of the XIIth International Congress of Electron Microscopy, p. 610-611.

39. Beverley, S.M., and C.M. Coburn (1990), "Recurrent de novo appearance of small linear DNAs in Leishmania major and relationship to extra-chromosomal DNAs observed in other species", Mol. Biochem. Parasitol. 42: 133-141.

38. Beverley, S.M. (1990), "Enzymatic amplification of RNA by Polymerase Chain Reaction", in Ausubel, F., Brent, R., Kingston, R., Moore, D., Seidman, J., Smith, J.A., and Struhl, K., Current Protocols in Molecular Biology, Greene Publishing Associates, New York, pages 15.4.1-15.4.6.

37.  Kapler, G.M., C.M. Coburn, and S.M. Beverley (1990), "Stable Transfection of the human parasite Leishmania delineates a 30 kb region sufficient for extra-chromosomal replication and expression", Mol. Cell. Biol.10: 1084-1094.

36.  Lopes, A.H. de C.S., D. Iovannisci, M. Petrillo-Peixoto, D. McMahon-Pratt, and S.M. Beverley (1990), "Evolution of nuclear DNA and the occurrence of sequences related to new small chromosomal DNAs in the trypanosomatid genus Endotrypanum", Mol. Biochem. Parasitol. 40: 151-162.

35. Ellenberger, T.E., J.E. Wright, A. Rosowsky, and S.M. Beverley (1989), "Wild-type and drug-resistant Leishmania major hydrolyze methotrexate to N-10-methyl-4-deoxy-4-aminopteroate without accumulation of methotrexate polyglutamates", J. Biol. Chem. 264: 15960-15966.

34. Kapler, G.M., and S.M. Beverley (1989), "Transcriptional mapping of the amplified region encoding the dihydrofolate reductase-thymidylate synthase of Leishmania major reveals a high density of transcripts, including overlapping and antisense RNAs", Mol. Cell. Biol.  9: 3959-3972.

33. Ellenberger, T.E., and S.M. Beverley (1989), "Multiple drug resistance linked to conservative amplification of the H region in Leishmania major", J. Biol. Chem. 264: 15094-15103.

32. Iovannisci, D.M., and S.M. Beverley (1989), "Structural alterations of chromosome 2 in Leishmania major as evidence for diploidy, including spontaneous amplification of the mini-exon array".  Mol. Biochem. Parasitol. 34:177-188.

31. Petrillo-Peixoto, M.L., and S.M. Beverley (1989), "Amplification of a new region of DNA in an unselected laboratory stock of Leishmania tarentolae:  the T region", J. Protozoology 36: 257-261.

30. Beverley, S.M. (1989), "Estimation of circular DNA size using gamma-irradiation and pulsed field electrophoresis", Anal. Biochem. 177: 110-114.

29. Beverley, S.M., and M.L. Petrillo-Peixoto (1988), “Naturally-occurring gene amplifications conferring drug resistance in Leishmania tarentolae”.  Memorias do Instituto Owaldo Cruz, Vol. 83, Suppl. I,  p. 330-333.

28. Petrillo-Peixoto, M.L., and S.M. Beverley (1988), “Amplified DNAs in laboratory stocks of Leishmania tarentolae:  extrachromosomal circles structurally and functionally similar to the inverted H region amplification of methotrexate-resistant L. major”Mol. Cell. Biol. 8: 5188-5199.

27. Beverley, S.M., T.E. Ellenberger, and M.L. Petrillo-Peixoto (1989), "Unstable and stable gene amplification in methotrexate-resistant Leishmania major and natural isolates of Leishmania tarentolae, Leishmaniasis:  The Current Status and New Strategies for Control,  D.T. Hart, Ed., Plenum Press, New York p. 873-878.

26. Beach, D.H., L.J. Goad, J.D. Berman, T.E. Ellenberger, S.M. Beverley, and G.G. Holz Jr. (1989), "Effects of a squalene-2, 3-epoxidase inhibitor on propagation and sterol biosynthesis of Leishmania promastigotes and amastigotes", in Leishmaniasis:  The current status and New Strategies for Control,  D.T. Hart, Ed., Plenum Press, New York, p. 885-890.

25. Beverley, S.M. (1988), "Characterization of the "unusual" mobility of large circular DNAs in pulsed field-gradient electrophoresis", Nucleic Acids Res. 16: 925-938.

24. Beverley, S.M., T.E. Ellenberger, D.M. Iovannisci, G.M. Kapler, M. Petrillo-Peixoto, and B.J. Sina. (1988), "Gene amplification in Leishmania", P.T. Englund, P.T., and A. Sher.  Biology of Parasitism, MBL Lectures in Biology, Vol 9. Alan Liss, Publishers, New York, pp 431-448.

23. Petrillo Peixoto, M., and S.M. Beverley (1987), "In vitro activity of sulfonamides and sulfones on promastigotes of Leishmania major", Antimicrobial Agents & Chemotherapy 31: 1575-8.

22. Ellenberger, T.E., and S.M. Beverley (1987), "Biochemistry and regulation of folate and methotrexate transport in Leishmania major", J. Biol. Chem. 262: 10053-58.

21. Ellenberger, T.E., and S.M. Beverley (1987), "Reductions in methotrexate and folate uptake in methotrexate-resistant lines of Leishmania major are independent of gene amplification" J. Biol. Chem. 262: 13501-13506.

20. Beverley, S.M., R.B. Ismach, and D. McMahon-Pratt (1987), "Evolution of the genus Leishmania as revealed by comparisons of nuclear DNA restriction fragments", Proc. Natl. Acad. Sci. USA 84: 484-488. 

19. Kapler, G.M., K. Zhang, and S.M. Beverley (1987), "Sequence and S1 nuclease mapping of the 5' region of the dihydrofolate reductase-thymidylate synthase gene of Leishmania major", Nucleic Acids Research 15: 3369-3383.

18. Beverley, S.M., R.B. Ismach, and D. McMahon-Pratt (1986), "Evolution of the genus Leishmania Ross (1903) as revealed by comparisons of nuclear DNA restriction fragment patterns", in Rioux, J.-A., Leishmania:  Taxonomy and Phylogeny Applications to Ecology and Epidemiology  Proceedings of International colloquium at  Montpellier July 2-6 1984    Institut Mediterranean D'Etudes Epidemiologique et Ecologiques Press, Montepellier, p. 265-267.

17. Beverley, S.M., T.E. Ellenberger, and J.S. Cordingley (1986), "Primary structure of the gene encoding the bifunctional dihydrofolate reductase-thymidylate synthase of Leishmania major", Proc. Natl. Acad. Sci USA 83: 2585- 2588.

16. Beverley, S.M. and A.C. Wilson (1985), "Ancient Origin for Hawaiian Drosophilinae Inferred from Protein Comparisons", Proc. Natl. Acad. Sci. USA 82: 4800-4804.

15. Beverley, S.M., J.A. Coderre, D.V. Santi and R.T. Schimke (1984), "Unstable DNA Amplifications in methotrexate- resistant Leishmania consist of extra-chromosomal circles which relocalize during stabilization", Cell 38: 431-9.

14. Federspiel, N.A., S.M. Beverley, J. Schilling, and R.T. Schimke (1984), "Novel DNA rearrangements are associated with dihydrofolate reductase gene amplification", J. Biol. Chem. 259: 9127-9140.

13. Beverley, S.M. and A.C. Wilson (1984), "Molecular Evolution in Drosophila and the Higher Diptera, II:  A Time Scale for Dipteran Evolution", J. Mol. Evol. 21: 1-13.

12. Garrett, C.E., J.A. Coderre, T.D. Meek, E.P. Garvey, D.M. Claman, S.M. Beverley and D.V. Santi (1983), "A bifunctional thymidylate synthase-dihydrofolate reductase in protozoa",  Mol. Biochem. Parasitology. 11: 257-265.

11. Coderre, J.A., S.M. Beverley, R.T. Schimke and D.V. Santi (1983), "Overproduction of a Bifunctional Thymidylate Synthase-Dihydrofolate Reductase and DNA Amplification in Methotrexate-Resistant Leishmania tropica", Proc. Natl. Acad. Sci. USA 80: 2132-2136.

10. Johnston, R.N., S.M. Beverley and R.T. Schimke (1983), "Rapid spontaneous dihydrofolate reductase gene amplification shown by fluorescence-activated cell sorting", Proc. Natl. Acad. Sci. 80: 3711-3715.

9. Schimke, R.T., S.M. Beverley, P.C. Brown, R. Cassin, N. Federspiel, C. Gasser, A. Hill, R. Johnston, B. Mariani,  E. Mosse, H. Rath, D. Smouse and T. Tlsty (1983), "Drug Resistance and Gene Amplification in Eukaryotic Cells", in Singer, T.P. and R.N. Ondarza, Mechanism of Drug Action, Academic Press, New York, p 107-117.

8. Santi, D.V., J.A. Coderre, S.M. Beverley and R.T. Schimke (1983), "Methotrexate-Resistant Leishmania tropica: A Model for Drug Resistance in Pathogenic Protozoa", Third John Jacob Abel Symposium on Drug Development: Molecular Parasitology, Academic Press, p. 107-121.

7. Schimke, R.T., S.M. Beverley, P.C. Brown, R. Cassin, N. Federspiel, C. Gasser, A. Hill, R. Johnston, B. Mariani, E. Mosse, H. Rath, D. Smouse and T. Tlsty (1983), "Gene Amplification and Drug Resistance in Cultured Animal Cells", in Cancer Treatment Reviews (International Symposium at Regensburg, FRG).

6. Beverley, S.M. and A.C. Wilson (1982), "Molecular Evolution in Drosophila and the Higher Diptera:  I.  Micro-complement Fixation Studies of a Larval Hemolymph Protein", J. Mol. Evol. 18: 251-264.

5. Schilling, J., S.M. Beverley, C. Simonsen, G. Crouse, D. Setzer, J. Feagin, M. McGrogan, N. Kohlmiller, R.T. Schimke (1982), "Dihydrofolate reductase gene structure and variable structure of amplified DNA in mouse cell lines", in R.T. Schimke, ed., Gene Amplification, Cold Spring Harbor Laboratory, p. 149 - 154.

4. Brown, P.C., S.M. Beverley and R.T. Schimke (1981), "Relationship of Amplified Dihydrofolate Reductase Genes to Double Minute Chromosomes in Unstably Resistant Mouse Fibroblast Cell Lines", Mol. Cell. Biology 1: 1077- 1083.

3. Haber, D.A., S.M. Beverley, M. Kiely and R.T. Schimke (1981) "Properties of an Altered Dihydrofolate Reductase Encoded by Amplified Genes in Cultured Mouse Fibroblasts", J. Biol. Chem. 256: 9501-9510.

2. Zimmer, E.A., S.L. Martin, S.M. Beverley, Y.W. Kan and A.C. Wilson (1980), "Rapid Duplication and Loss of Genes Coding for the Alpha Chain of Hemoglobin", Proc. Natl. Acad. Sci. USA 77: 2158-2162.

1. Beverley, S.M. (1979), "Molecular Evolution in Drosophila and the Higher Diptera", Ph.D. Thesis, University of California, Berkeley, 424 pp.